FM19G11 | Tocris Bioscience 6653 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FM19G11

catalog :

6653

quantity :

25 mg

price :

463 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6653

SKU :

6653/25

product name :

FM19G11

description :

HIF -subunit inhibitor

target :

HIF Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

463.4

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Hypoxia inducible factor (HIF) -subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIF isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O6-methylguanine DNA methyltransferase (MGMT) via HIF1 pathway, under normal and hypoxic conditions in glioblastoma cell lines.

catalog number base :

6653

product keywords :

hypoxia inducible factor alpha subunit HIF1a HIF2a HIF3a inhibits inhibitors pluripotency genes stemness Hypoxia Inducible Factors Other Differentiation Products 6653, Hypoxia Inducible Factors, Hypoxia Inducible Factor

extended description :

HIF -subunit inhibitor

chemical name text :

2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate

formula :

C 23 H 17 N 3 O 8

formula text :

C23H17N3O8

cas num :

329932-55-0

2020 USD :

449

2021 USD :

463 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage