FM19G11 | Tocris Bioscience 6653/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FM19G11

catalog :

6653/5

quantity :

5 mg (also 25 mg)

price :

150 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6653 - FM19G11 C23H17N3O8 CAS No. 329932-55-0

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6653

SKU :

6653/5

product name :

FM19G11

description :

HIF -subunit inhibitor

target :

HIF Inhibitors

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

463.4

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FM19G11 is a hypoxia inducible factor (HIF) -subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIF isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O6-methylguanine DNA methyltransferase (MGMT) via HIF1 pathway, under normal and hypoxic conditions in glioblastoma cell lines.

product keywords :

hypoxia inducible factor alpha subunit HIF1a HIF2a HIF3a inhibits inhibitors pluripotency genes stemness Hypoxia Inducible Factors Other Differentiation Products 6653, Hypoxia Inducible Factors, Hypoxia Inducible Factor

extended description :

HIF -subunit inhibitor

chemical name text :

2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate

formula :

C23H17N3O8

formula text :

C23H17N3O8

cas num :

329932-55-0

USD :

148

USD 2025 :

150 USD

product details :

HIF -subunit inhibitor

more info or order :

Tocris Bioscience product webpage