product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
FM19G11
catalog :
6653/5
quantity :
5 mg (also 25 mg)
price :
150 USD
more info or order :
Tocris Bioscience product webpage
image
image 1 :
Tocris Bioscience 6653/5 image 1
Cat.No. 6653 - FM19G11 C23H17N3O8 CAS No. 329932-55-0
product information
brand :
Tocris
catalog number base :
6653
SKU :
6653/5
product name :
FM19G11
units size :
5 mg (also 25 mg)
description :
HIF -subunit inhibitor
target :
HIF Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
463.4
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
review stars :
4
details of functionality :
FM19G11 is a hypoxia inducible factor (HIF) -subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIF isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O6-methylguanine DNA methyltransferase (MGMT) via HIF1 pathway, under normal and hypoxic conditions in glioblastoma cell lines.
top caption :
HIF -subunit inhibitor
extended description :
HIF -subunit inhibitor
chemical name text :
2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate
formula :
C23H17N3O8
formula text :
C23H17N3O8
cas num :
329932-55-0
USD :
150 USD
product details :
HIF -subunit inhibitor
storage :
Store at +4°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK