chemical

Roflumilast

6641

10 mg (also 50 mg)

53 USD

6641

6641/10

Roflumilast

Potent and selective PDE4 inhibitor

Phosphodiesterase Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

403.21

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Potent and selective PDE4 inhibitor (IC50 values are 0.2 to 4.3 nM for various splice variants of PDE4). Exhibits > 1000-fold selectivity for PDE4 over other PDE family members. Demonstrates effects on functioning of neutrophils, CD4+ and CD8+ T-cells, endothelial, epithelial and smooth muscle cells, as well as fibroblasts, in vitro . Attenuates lung inflammation, mucociliary malfunction, lung fibrosis, oxidative stress, pulmonary vascular remodeling and pulmonary hypertension in animal models of COPD disease mechanisms.

6641

Roflumilast potent selective phosphodiesterase 4 PDE4 inhibitors inhibits PDE4A PDE4B PDE4C PDE4D Phosphodiesterases 6641,

Potent and selective PDE4 inhibitor

3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide

C 17 H 14 Cl 2 F 2 N 2 O 3

C17H14Cl2F2N2O3

162401-32-3

51

53 USD

Store at +4°C