chemical

LYN 1604 dihydrochloride

6617/10

10 mg (also 50 mg)

144 USD

6617

6617/10

LYN 1604 dihydrochloride

Potent UNC-51-like kinase 1 (ULK1) agonist

ULK1

10 mg (also 50 mg)

Small Molecules

98%

Store at -20°C

657.54

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LYN 1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) agonist (EC50 = 18.94 nM). In MDA-MB-231 cells, LYN 1604 induces upregulation of Beclin-1, LC3-I and LC3-II, as well as degradation of p62. LYN 1604 induces cell death (IC50 = 1.66 M) via the ULK complex involving both autophagy and apoptosis pathway effectors (e.g. ATF3, RAD21, and caspase-3); this effect is reversible by the autophagy inhibitor 3-methyladenine (Cat. No. 3977). LYN 1604 inhibits tumor growth in a mouse xenograft model, decreases bone loss in a mouse model of osteoporosis and reduces the formation of TRAP-positive multinucleated cells.

LYN1604 potent UNC-51-like kinase 1 ULK1 agonists agonism activators activates autophagy apoptosis Other Kinases Autophagy Apoptosis Inducers 6617, Autophagy-related protein 1 homolog, Unc-51-like kinase 1

Potent UNC-51-like kinase 1 (ULK1) agonist

2-[Bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]ethanone dihydrochloride

C33H43Cl2N3O2.2HCl

C33H43Cl2N3O2.2HCl

2310109-38-5

160

144 USD

Potent UNC-51-like kinase 1 (ULK1) agonist

A170, ATG1, ATG1 autophagy related 1 homolog, ATG1A, EBIAP, EC 2.7.11, EC 2.7.11.1, FLJ38455, FLJ46475, hATG1, KIAA0722, ORCA, OSIL, PDB3, Sequestosome 1, serine/threonine-protein kinase ULK1, SQSTM1, UNC51, unc-51 (C. elegans)-like kinase 1, Unc51.1, Unc-51-like kinase 1, unc-51-like kinase 1 (C. elegans), ZIP3