dTRIM 24 | Tocris Bioscience 6607 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

dTRIM 24

catalog :

6607

quantity :

5 mg

price :

367 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6607

SKU :

6607/5

product name :

dTRIM 24

description :

TRIM24 degrading PROTAC

target :

Active Degraders

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

1113.3

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PROTAC composed of the TRIM24 ligand IACS-9571 conjugated to a VHL ligand. Displays dose- and time-dependent degradation of TRIM24 in cells, with maximum degradation achieved at 5 M. Degradation phenotypically mirrors genetic deletion of TRIM24. Demonstrates antiproliferative effects in MOLM-13 cells. Cell permeable. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

catalog number base :

6607

product keywords :

dTRIM24 active degraders degrades PROTAC proteolysis targeting chimera PROTACs TRIM24 Tripartite motif-containing 24 transcriptional intermediary factor 1alpha TIF1 targeted protein degradation tpd Active Degraders Other Transcription Factors 6607, target protein knockdown, PROTAC, SNIPER

extended description :

TRIM24 degrading PROTAC

chemical name text :

(2S,4R)-1-((S)-15-(tert-Butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxami

formula :

C 55 H 68 N 8 O 13 S 2

formula text :

C55H68N8O13S2

cas num :

2170695-14-2

2020 USD :

356

2021 USD :

367 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage