dTRIM 24 | Tocris Bioscience 6607/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

dTRIM 24

catalog :

6607/5

quantity :

5 mg

price :

404 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Ma D, Yuan Q, Peng F, Paredes V, Zeng H, Osikpa E, et al. Engineered PROTAC-CID Systems for Mammalian Inducible Gene Regulation. J Am Chem Soc. 2023;: pubmed publisher

image

image 1 :

Cat.No. 6607 - dTRIM 24 C55H68N8O13S2 CAS No. 2170695-14-2

product information

brand :

Tocris

master code :

6607

SKU :

6607/5

rank :

0.06

product name :

dTRIM 24

description :

TRIM24 Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

sizes available :

5 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

dTRIM 24 is a degrader (PROTAC ) composed of the TRIM24 ligand IACS-9571 conjugated to a VHL ligand. Displays dose- and time-dependent degradation of TRIM24 in cells, with maximum degradation achieved at 5 M. Degradation phenotypically mirrors genetic deletion of TRIM24. Demonstrates antiproliferative effects in MOLM-13 cells. Cell permeable. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

extended description :

TRIM24 Degrader (PROTAC )

chemical name text :

(2S,4R)-1-((S)-15-(tert-Butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxami

formula :

C 55 H 68 N 8 O 13 S 2

formula text :

C55H68N8O13S2

cas num :

2170695-14-2

USD :

404 USD

product details :

TRIM24 Degrader (PROTAC )

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage