dBRD9 | Tocris Bioscience 6606 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

dBRD9

catalog :

6606

quantity :

5 mg

price :

385 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Loo C, Gatchalian J, Liang Y, Leblanc M, Xie M, Ho J, et al. A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function. Immunity. 2020;53:143-157.e8 pubmed publisher

product information

brand :

Tocris

master code :

6606

SKU :

6606/5

product name :

dBRD9

description :

Potent and selective BRD9 degrading PROTAC

target :

Active Degraders

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

856.75

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide (Cat. No. 6302). Potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). Does not degrade BRD4 or BRD7 at concentrations up to 5 M. Displays antiproliferative effects in human AML cell lines. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

catalog number base :

6606

product keywords :

2170679-45-3 BRD9 degrading active degraders PROTAC PROTACs Proteolysis Targeting Chimeras targeted protein degradation tpd BAF complex factor bromodomains cereblon e3 ligase potent selective Active Degraders 6606, target protein knockdown, PROTAC, SNIPER

extended description :

Potent and selective BRD9 degrading PROTAC

chemical name text :

2-[[[4-(1,2-Dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2-6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]acetamide dihydrochloride

formula :

C 40 H 45 N 7 O 10 .2HCl

formula text :

C40H45N7O10.2HCl

cas num :

2341840-98-8

2020 USD :

370

2021 USD :

385 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage