dBRD9 | Tocris Bioscience 6606/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

dBRD9

catalog :

6606/5

quantity :

5 mg

price :

424 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Loo C, Gatchalian J, Liang Y, Leblanc M, Xie M, Ho J, et al. A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function. Immunity. 2020;53:143-157.e8 pubmed publisher

product information

brand :

Tocris

master code :

6606

SKU :

6606/5

rank :

0.06

product name :

dBRD9

description :

Potent and selective BRD9 Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

sizes available :

5 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

dBRD9 is a potent and selective Degrader (PROTAC ) of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide (Cat. No. 6302). Does not degrade BRD4 or BRD7 at concentrations up to 5 M. Displays antiproliferative effects in human AML cell lines. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

extended description :

Potent and selective BRD9 Degrader (PROTAC )

chemical name text :

2-[[[4-(1,2-Dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2-6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]acetamide dihydrochloride

formula :

C 40 H 45 N 7 O 10 .2HCl

formula text :

C40H45N7O10.2HCl

cas num :

2341840-98-8

USD :

424 USD

product details :

Potent and selective BRD9 Degrader (PROTAC )

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage