chemical

dTAG-13

6605

5 mg

430 USD

6605

6605/5

dTAG-13

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Active Degraders

Small Molecules

5 mg

98%

1049.18

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Degrader targeting mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. Application of dTAG-13 induces rapid, reversible and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo . dTAG is generalizable to a range of fusion proteins; useful as an alternative to genetic methods for target validation. . Negative control (Cat. No. 6916) also available. . FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in. Custom knock-in cell lines for the dTAG and aTAG platforms are available from our sister brand R&D Systems . Email TPD@bio-techne.com to enquire. . Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.

6605

dTAG13 degraders degrades degradation FKBP12F36V fusion protein mutant PROTAC proteolysis targeting chimera cereblon PROTACs TAG Degradation Platform 6605, target protein knockdown, PROTAC, SNIPER

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester

C 57 H 68 N 4 O 15

C57H68N4O15

2064175-41-1

409

430 USD

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