SPRi 3 | Tocris Bioscience 6597/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SPRi 3

catalog :

6597/10

quantity :

10 mg (also 50 mg)

price :

244 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

MasterCode :

6597

SKU :

6597/10

product name :

SPRi 3

target :

Other Reductase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

262.3

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SPRi 3 is a potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR). Inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4+ T cells. Suppresses proliferation of human effector CD4+ T cells following stimulation. Reduces SPR activity in mouse primary cultures of sensory neurons (IC50 = 450 nM). Ameliorates colitis, suppressing the intestinal infiltration of T cells and other immune cells in vivo . Also reduces immune-cell infiltration into mouse lungs. Reduces neuropathic and inflammatory pain in mouse models.

extended description :

Potent sepiapterin reductase (SPR) inhibitor; attenuates proliferation of CD4+ T cells

chemical name text :

N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide

formula :

C 14 H 18 N 2 O 3

formula text :

C14H18N2O3

cas num :

1292285-54-1

USD :

244 USD

product details :

Potent sepiapterin reductase (SPR) inhibitor; attenuates proliferation of CD4+ T cells

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage