TAK 242 | Tocris Bioscience 6587/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TAK 242

catalog :

6587/5

quantity :

5 mg

price :

242 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Yadav S, Singh A, Kant R, Surolia A. TLR4 activation by lysozyme induces pain without inflammation. Front Immunol. 2023;14:1065226 pubmed publisher
Shabir K, Gharanei S, Orton S, Patel V, Chauhan P, Karteris E, et al. Asprosin Exerts Pro-Inflammatory Effects in THP-1 Macrophages Mediated via the Toll-like Receptor 4 (TLR4) Pathway. Int J Mol Sci. 2022;24: pubmed publisher
Kisipan M, Ojoo R, Kanui T, Abelson K. Bodyweight, locomotion, and behavioral responses of the naked mole rat (Heterocephalus glaber) to lipopolysaccharide administration. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2022;208:493-504 pubmed publisher
Peyravian N, Sun E, Dikici E, Deo S, Daunert S, Toborek M. Opioid Antagonist Nanodrugs Successfully Attenuate the Severity of Ischemic Stroke. Mol Pharm. 2022;19:2254-2267 pubmed publisher
Schwertz H, Rowley J, Portier I, Middleton E, Tolley N, Campbell R, et al. Human platelets display dysregulated sepsis-associated autophagy, induced by altered LC3 protein-protein interaction of the Vici-protein EPG5. Autophagy. 2022;18:1534-1550 pubmed publisher
Grigoryeva L, Cianciotto N. Human macrophages utilize a wide range of pathogen recognition receptors to recognize Legionella pneumophila, including Toll-Like Receptor 4 engaging Legionella lipopolysaccharide and the Toll-like Receptor 3 nucleic-acid sensor. PLoS Pathog. 2021;17:e1009781 pubmed publisher

image

image 1 :

Cat.No. 6587 - TAK 242 C15H17ClFNO4S CAS No. 243984-11-4

product information

brand :

Tocris

MasterCode :

6587

SKU :

6587/5

product name :

TAK 242

target :

Toll-like Receptor Inhibitors

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

361.82

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TAK 242 is a toll-like receptor 4 (TLR4) signaling inhibitor. Binds to intracellular domain of TLR4. Inhibits LPS-induced cytokine production in vitro (IC50 values are 1.3, 1.3 and 3.2 nM for IL-6, TNF and NO production). Reduces lesion volume in a mouse model of cerebral cavernous malformations (CCMs). Also attenuates increased cytokine levels in a mouse sepsis model, when given in combination with ceftazidime. Cell permeable.

extended description :

TLR4 signaling inhibitor

chemical name text :

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate

formula :

C 15 H 17 ClFNO 4 S

formula text :

C15H17ClFNO4S

cas num :

243984-11-4

USD :

242 USD

product details :

TLR4 signaling inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage