PKUMDL WQ 2101 | Tocris Bioscience 6580/5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PKUMDL WQ 2101

catalog :

6580/5

quantity :

5 mg (also 25 mg)

price :

90 USD

citations: 1

Reference
Soflaee M, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, et al. Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nat Commun. 2022;13:2698 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6580

SKU :

6580/5

product name :

PKUMDL WQ 2101

description :

Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)

target :

Dehydrogenase Inhibitors

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

317.25

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 M). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 M in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.

product keywords :

PKUMDLWQ2101 Phosphoglycerate dehydrogenase PHGDH allosteric inhibitor serine biosynthesis negative modulator NAM Other Dehydrogenases 6580,

extended description :

Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)

chemical name text :

2,4-Dihydroxy-N -(2-hydroxy-5-nitrobenzylidene)benzohydrazide

formula :

C14H11N3O6

formula text :

C14H11N3O6

cas num :

304481-72-9

USD :

USD 2025 :

90 USD

product details :

Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)