GT 949 | Tocris Bioscience 6578/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GT 949

catalog :

6578/10

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Zhang R, DU W, Prober D, Du J. Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors. Cell Rep. 2019;27:2871-2880.e2 pubmed publisher

image

image 1 :

Cat.No. 6578 - GT 949 C30H37N7O2 CAS No. 460330-27-2

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6578

SKU :

6578/10

product name :

GT 949

description :

Potent and selective positive allosteric modulator of EAAT2

target :

Glutamate (EAAT) Transporter Compounds

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

527.66

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GT 949 is a potent and selective EAAT2 positive allosteric modulator (EC50 = 0.26 nM). Enhances the glutamate translocation rate, with no effect on substrate interaction. Enhances glutamate uptake by cultured astrocytes by approximately 58%. Exhibits no significant effect on DAT, SERT and NET or NMDA receptors. Neuroprotective in an in vitro model of excitotoxicity.

product keywords :

GT949 selective EAAT2 positive allosteric modulators PAM Glutamate Transporters 6578,

extended description :

Potent and selective positive allosteric modulator of EAAT2

chemical name text :

3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one

formula :

C30H37N7O2

formula text :

C30H37N7O2

cas num :

460330-27-2

USD :

243

USD 2025 :

219 USD

product details :

Potent and selective positive allosteric modulator of EAAT2

more info or order :

Tocris Bioscience product webpage