chemical

Pyridone 6

6577

10 mg (also 50 mg)

191 USD

6577

6577/10

Pyridone 6

Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

JAK Kinase Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

309.34

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Potent pan-JAK inhibitor; ATP-competitive inhibitor of JAK 1/2/3 and Tyk2 (IC50 values are 1, 5, 15 and 1 nM, respectively). Inhibits other kinases tested at 130 nM to 10 M. Inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks STAT5 phosphorylation. Also inhibits Th1 and Th2 development, and promotes Th17 differentiation from naive T cells. When used in combination with Retinoic acid, LY 294002 and CCG 1423, it induces intermediate mesoderm differentiation from ESCs. Inhibits growth of primary myeloma cells grown in the presence of bone marrow stromal cells. Cell-permeable.

6577

CMP 6 Pyridon 6 pan JAK inhibitor I potent ATP competitive JAK 1 JAK2 JAK3 Tyk2 STAT5 mesoderm differentiation myeloma JAK inhibitor I JAK Kinase ESCs and iPSC Cardiomyocyte Stem Cells 6577,

Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one

C 18 H 16 FN 3 O

C18H16FN3O

457081-03-7

185

191 USD

JAK inhibitor I

Store at -20°C