Pyridone 6 | Tocris Bioscience 6577/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Pyridone 6

catalog :

6577/10

quantity :

10 mg (also 50 mg)

price :

241 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Chou T, Chang N, Krishnagiri M, Patel A, Lindman M, Angel J, et al. Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB. Cell Death Dis. 2021;12:756 pubmed publisher

image

image 1 :

Cat.No. 6577 - Pyridone 6 C18H16FN3O CAS No. 457081-03-7

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6577

SKU :

6577/10

product name :

Pyridone 6

description :

Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

target :

JAK Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

309.34

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Pyridone 6 is a potent pan-JAK inhibitor; ATP-competitive inhibitor of JAK 1/2/3 and Tyk2 (IC50 values are 1, 5, 15 and 1 nM, respectively). Inhibits other kinases tested at 130 nM to 10 M. Inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks STAT5 phosphorylation. Also inhibits Th1 and Th2 development, and promotes Th17 differentiation from naive T cells. When used in combination with Retinoic acid, LY 294002 and CCG 1423, it induces intermediate mesoderm differentiation from ESCs. Inhibits growth of primary myeloma cells grown in the presence of bone marrow stromal cells. Cell-permeable.

product keywords :

CMP 6 Pyridon 6 pan JAK inhibitor I potent ATP competitive JAK 1 JAK2 JAK3 Tyk2 STAT5 mesoderm differentiation myeloma JAK inhibitor I JAK JAK Kinase ESCs and iPSC Cardiomyocyte Stem Cells 6577,

extended description :

Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

chemical name text :

2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one

formula :

C18H16FN3O

formula text :

C18H16FN3O

cas num :

457081-03-7

USD :

238

USD 2025 :

241 USD

product details :

Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

alt names :

JAK inhibitor I

more info or order :

Tocris Bioscience product webpage