THAL SNS 032 | Tocris Bioscience 6532 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

THAL SNS 032

catalog :

6532

quantity :

5 mg

price :

378 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Kaji T, Koga H, Kuroha M, Akimoto T, Hayata K. Characterization of cereblon-dependent targeted protein degrader by visualizing the spatiotemporal ternary complex formation in cells. Sci Rep. 2020;10:3088 pubmed publisher

product information

brand :

Tocris

master code :

6532

SKU :

6532/5

product name :

THAL SNS 032

description :

Potent and selective Cdk9 degrading PROTAC

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

869.02

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PROTAC comprising the cyclin-dependent kinase inhibitor SNS 032 (Cat. No. 4075) conjugated to the cereblon E3 ligase ligand, thalidomide (Cat. No. 0652). Potent, selective and cereblon-dependent degrader of Cdk9 (EC50 = 4 nM). Displays 15-fold selectivity for Cdk9 over other CDKs (EC50 values are 62, 171 and 398 nM for Cdk2, Cdk1 and Cdk7, respectively). Induces complete degradation of Cdlk9 at 250 nM in MOLT4 cells. Inhibits proliferation of leukemia cell lines. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

catalog number base :

6532

product keywords :

THALSNS032 potent selective CDK9 active degraders degrades PROTAC PROTACs proteolysis targeting chimera targeted protein degradation tpd Active Degraders Cyclin-dependent Kinase 6532,

extended description :

Potent and selective Cdk9 degrading PROTAC

chemical name text :

N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide

formula :

C 40 H 52 N 8 O 10 S 2

formula text :

C40H52N8O10S2

cas num :

2139287-33-3

2020 USD :

363

2021 USD :

378 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage