THAL SNS 032 | Tocris Bioscience 6532/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

THAL SNS 032

catalog :

6532/5

quantity :

5 mg

price :

416 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Kaji T, Koga H, Kuroha M, Akimoto T, Hayata K. Characterization of cereblon-dependent targeted protein degrader by visualizing the spatiotemporal ternary complex formation in cells. Sci Rep. 2020;10:3088 pubmed publisher

product information

brand :

Tocris

master code :

6532

SKU :

6532/5

rank :

0.06

product name :

THAL SNS 032

description :

Potent and selective Cdk9 Degrader (PROTAC )

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

sizes available :

5 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

THAL SNS 032 is a degrader (PROTAC ) comprising the cyclin-dependent kinase inhibitor SNS 032 (Cat. No. 4075) conjugated to the cereblon E3 ligase ligand, thalidomide (Cat. No. 0652). Potent, selective and cereblon-dependent degrader of Cdk9 (EC50 = 4 nM). Displays 15-fold selectivity for Cdk9 over other CDKs (EC50 values are 62, 171 and 398 nM for Cdk2, Cdk1 and Cdk7, respectively). Induces complete degradation of Cdk9 at 250 nM in MOLT4 cells. Inhibits proliferation of leukemia cell lines. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

extended description :

Potent and selective Cdk9 Degrader (PROTAC )

chemical name text :

N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide

formula :

C 40 H 52 N 8 O 10 S 2

formula text :

C40H52N8O10S2

cas num :

2139287-33-3

USD :

416 USD

product details :

Potent and selective Cdk9 Degrader (PROTAC )

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage