EPZ 015666 | Tocris Bioscience 6516/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

EPZ 015666

catalog :

6516/5

quantity :

5 mg (also 25 mg)

price :

189 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Fong J, Pignata L, Goy P, Kawabata K, Lee S, Koh C, et al. Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Cancer Cell. 2019;36:194-209.e9 pubmed publisher

image

image 1 :

Cat.No. 6516 - EPZ 015666 C20H25N5O3 CAS No. 1616391-65-1

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6516

SKU :

6516/5

product name :

EPZ 015666

description :

Potent and selective PRMT5 inhibitor

target :

Protein Arginine Methyltransferase Inhibitors

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

383.44

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

EPZ 015666 is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50 = 22 nM, Ki = 5 nM). Displays selectivity for PRMT5 over a panel of 20 other protein methyltransferases. Exhibits dose-dependent antitumor effects in multiple mantle cell lymphoma (MCL) xenograft models. Orally bioavailable.

product keywords :

EPZ015666 GSK3235025 potent selective PRMT5 protein arginine methytransferase 5 inhibitors inhibits Protein Arginine Methyltransferases 6516,

extended description :

Potent and selective PRMT5 inhibitor

chemical name text :

N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide

formula :

C20H25N5O3

formula text :

C20H25N5O3

cas num :

1616391-65-1

USD :

209

USD 2025 :

189 USD

product details :

Potent and selective PRMT5 inhibitor

more info or order :

Tocris Bioscience product webpage