LNT 1 | Tocris Bioscience 6510/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LNT 1

catalog :

6510/5

quantity :

5 mg

price :

246 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Li J, M Saville K, Ibrahim M, Zeng X, McClellan S, Angajala A, et al. NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells. NAR Cancer. 2021;3:zcab044 pubmed publisher
Ward T, McHugh P, Durant S. Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS ONE. 2017;12:e0179278 pubmed publisher

product information

brand :

Tocris

MasterCode :

6510

SKU :

6510/5

product name :

LNT 1

target :

Hydrolase Inhibitors

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

332.33

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LNT 1 is a potent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336 ). Cytotoxic to SW620 colorectal cancer cells in vitro ; induces DNA damage response.

extended description :

Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response

chemical name text :

1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

formula :

C 15 H 12 N 2 O 5 S

formula text :

C15H12N2O5S

cas num :

824983-91-7

USD :

246 USD

product details :

Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage