GSK 1702934A | Tocris Bioscience 6508/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 1702934A

catalog :

6508/10

quantity :

10 mg (also 50 mg)

price :

247 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Caires R, Garrud T, Romero L, Fern xe1 ndez Pe xf1 a C, V xe1 squez V, Jaggar J, et al. Genetic- and diet-induced ω-3 fatty acid enrichment enhances TRPV4-mediated vasodilation in mice. Cell Rep. 2022;40:111306 pubmed publisher

image

image 1 :

Cat.No. 6508 - GSK 1702934A C22H25N3O2S CAS No. 924377-85-5

product information

brand :

Tocris

catalog number base :

6508

SKU :

6508/10

product name :

GSK 1702934A

units size :

10 mg (also 50 mg)

description :

Potent and selective TRPC3/6 activator

target :

TRPC Channel Activators

category :

Small Molecules

purity :

98%

observed molecular weight :

395.52

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

review stars :

details of functionality :

GSK 1702934A is a potent and selective TRPC3/6 activator (EC50 = 80 and 440 nM for TRPC3 and 6, respectively). Exhibits no activity at TRPV4, TRPA1, M1, M4, CaV1.2, hERG, NaV1.5, or CXCR5 receptors at concentrations 10 mol/L. Induces TRPC3/6-currents in HEK293 cells transduced with recombinant human TRPC3/6. Directly activates TRPC channels through by-passing phospholipase-C signaling. Also induces calcium signals in HEK-TRPC6 cells (pEC50 = 6.6).

top caption :

Potent and selective TRPC3/6 activator

extended description :

Potent and selective TRPC3/6 activator

chemical name text :

1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one

formula :

C22H25N3O2S

formula text :

C22H25N3O2S

cas num :

924377-85-5

USD :

247 USD

product details :

Potent and selective TRPC3/6 activator

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage