PF 06651600 malonate | Tocris Bioscience 6506 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 06651600 malonate

catalog :

6506

quantity :

25 mg

price :

281 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6506

SKU :

6506/25

product name :

PF 06651600 malonate

description :

Potent and selective JAK3 inhibitor

target :

JAK Kinase Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

389.41

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective JAK3 inhibitor (IC50 = 33.1 M). Exhibits no significant activity against a panel of other kinases including JAK1, JAK2 and TYK2. Inhibits phosphorylation of STAT5, induced by IL-2, IL-4, IL-7 and IL-15. Suppresses Th1 and Th17 T-cell differentiation and function in vitro . Reduces paw swelling in a rat model of arthritis and reduces disease severity in a rat EAE model.

catalog number base :

6506

product keywords :

PF06651600 malonate JAK3 kinase inhibitors inhibits potent selective anti-inflammatory JAK Kinase 6506,

extended description :

Potent and selective JAK3 inhibitor

chemical name text :

1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate

formula :

C 15 H 19 N 5 O.C 3 H 4 O 4

formula text :

C15H19N5O.C3H4O4

cas num :

2140301-97-7

2020 USD :

281

2021 USD :

281 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage