PF 06651600 malonate | Tocris Bioscience 6506/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 06651600 malonate

catalog :

6506/5

quantity :

5 mg (also 25 mg)

price :

90 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6506 - PF 06651600 malonate C15H19N5O.C3H4O4 CAS No. 2140301-97-7

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6506

SKU :

6506/5

product name :

PF 06651600 malonate

description :

Potent and selective JAK3 inhibitor

target :

JAK Kinase Inhibitors

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

389.41

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PF 06551600 malonate is a potent and selective JAK3 inhibitor (IC50 = 33.1 M). Exhibits no significant activity against a panel of other kinases including JAK1, JAK2 and TYK2. Inhibits phosphorylation of STAT5, induced by IL-2, IL-4, IL-7 and IL-15. Suppresses Th1 and Th17 T-cell differentiation and function in vitro . Reduces paw swelling in a rat model of arthritis and reduces disease severity in a rat EAE model.

product keywords :

PF06651600 malonate JAK3 kinase inhibitors inhibits potent selective anti-inflammatory JAK 6506,

extended description :

Potent and selective JAK3 inhibitor

chemical name text :

1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate

formula :

C15H19N5O.C3H4O4

formula text :

C15H19N5O.C3H4O4

cas num :

2140301-97-7

USD :

USD 2025 :

90 USD

product details :

Potent and selective JAK3 inhibitor

more info or order :

Tocris Bioscience product webpage