MLN 4924 | Tocris Bioscience 6499/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MLN 4924

catalog :

6499/10

quantity :

10 mg (also 50 mg)

price :

181 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Planès R, Pinilla M, Santoni K, Hessel A, Passemar C, Lay K, et al. Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. Mol Cell. 2022;82:2385-2400.e9 pubmed publisher

image

image 1 :

Cat.No. 6499 - MLN 4924 C21H25N5O4S CAS No. 905579-51-3

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6499

SKU :

6499/10

product name :

MLN 4924

description :

Potent and selective NEDD8 activating enzyme (NAE) inhibitor; cell permeable

target :

NEDD8 Activating Enzyme (E1) Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

443.52

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MLN 4924 (TAK 924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50 = 4.7 nM). MLN 4924 exhibits selectivity over closely related enzymes UAE, UBA6, SAE, and ATG7 (IC50 = 1.5, 1.8, 8.2, and 10 M, respectively), and displays minimal activity at adenosine receptors and a panel of 12 cellular kinases. MLN 4924 exhibits cyotoxicity in several human tumor-derived cell lines and causes liver damage in SD rats, when given with TNF- . It blocks the NEDD8 pathway causing DNA damage in mice bearing HCT-116 xenografts. Cell permeable.

product keywords :

MLN4924 NEDD8 activating enzymes NAE inhibitor inhibitors inhibits neddylation cell permeable Pevonedistat TAK-924 Other Ligases 6499, ubrelatedenzymes, NEDD8 E1 Activating Enzyme Inhibitor, NAE Inhibitor, NAE1 Inhibitor

extended description :

Potent and selective NEDD8 activating enzyme (NAE) inhibitor; cell permeable

chemical name text :

[(1S,2S,4R)-4-[4-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamic acid ester

formula :

C21H25N5O4S

formula text :

C21H25N5O4S

cas num :

905579-51-3

USD :

173

USD 2025 :

181 USD

product details :

Potent and selective NEDD8 activating enzyme (NAE) inhibitor; cell permeable

alt names :

Pevonedistat,TAK-924

more info or order :

Tocris Bioscience product webpage