TASP 0277308 | Tocris Bioscience 6498/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TASP 0277308

catalog :

6498/5

quantity :

5 mg

price :

328 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6498 - TASP 0277308 C23H28Cl2N6O3S CAS No. 945725-50-8

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6498

SKU :

6498/5

product name :

TASP 0277308

description :

Potent and selective S1P1 receptor antagonist; inhibits angiogenesis

target :

Sphingosine-1-phosphate Receptor Antagonists

unit size :

5 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

539.48

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesis in vivo . TASP 0277308 also blocks VEGF-induced tube-formation of HUVECs in vitro and reverses or impairs the development of arthritis or mechano-allodynia.

product keywords :

TASP0277308 potent selective sphingosine 1-phosphate antagonists S1P1-receptors Sphingosine-1-phosphate Receptors Antiangiogenics 6498,

extended description :

Potent and selective S1P1 receptor antagonist; inhibits angiogenesis

chemical name text :

3,4-Dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methyl-1-piperazinyl)phenoxy]-4H-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide

formula :

C23H28Cl2N6O3S

formula text :

C23H28Cl2N6O3S

cas num :

945725-50-8

USD :

324

USD 2025 :

328 USD

product details :

Potent and selective S1P1 receptor antagonist; inhibits angiogenesis

more info or order :

Tocris Bioscience product webpage