GSK 2833503A | Tocris Bioscience 6497/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 2833503A

catalog :

6497/10

quantity :

10 mg

price :

557 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Caires R, Garrud T, Romero L, Fern xe1 ndez Pe xf1 a C, V xe1 squez V, Jaggar J, et al. Genetic- and diet-induced ω-3 fatty acid enrichment enhances TRPV4-mediated vasodilation in mice. Cell Rep. 2022;40:111306 pubmed publisher

image

image 1 :

Cat.No. 6497 - GSK 2833503A C18H21ClFN3OS CAS No. 1366234-01-6

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6497

SKU :

6497/10

product name :

GSK 2833503A

description :

Potent and selective TRPC6 and TRPC3 antagonist

target :

TRPC Channel Blockers

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

381.89

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 2833503A is a potent and selective TRPC6 and TRPC3 antagonist (IC50 = 3-16 nM and 21-100 nM, respectively). GSK 2833503A exhibits 63-fold selectivity over other ion channels, including other TRP channels, CaV1.2, hERG and NaV1.5. GSK 2833503A suppresses angiotensin II or endothelin-1-induced cardiac hypertrophy signaling in HEK293 cells in vitro and in cardiomyocytes.

product keywords :

GSK2833503A GSK503A TRPC3 TRPC6 transient receptor potential canonical channel anatagonists potent selective TRPC 6497,

extended description :

Potent and selective TRPC6 and TRPC3 antagonist

chemical name text :

[2-[(4-Chloro-2-fluorophenyl)amino]-5-methyl-4-thiazolyl][(2S,3S)-2,3-dimethyl-1-piperidinyl]methanone

formula :

C18H21ClFN3OS

formula text :

C18H21ClFN3OS

cas num :

1366234-01-6

USD :

534

USD 2025 :

557 USD

product details :

Potent and selective TRPC6 and TRPC3 antagonist

more info or order :

Tocris Bioscience product webpage