A 317491 sodium salt | Tocris Bioscience 6493 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 317491 sodium salt

catalog :

6493

quantity :

25 mg

price :

562 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6493

SKU :

6493/25

product name :

A 317491 sodium salt

description :

Selective, high affinity P2X3 and P2X2/3 antagonist; antinociceptive

target :

P2X Receptor Antagonists

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

609.54

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective, high affinity non-nucleotide P2X3 and P2X2/3 receptor antagonist (Ki values are 9, 22, 22 and 92 nM at human P2X2/3, rat P2X3, human P2X3 and rat P2X2/3, respectively); blocks recombinant human and rat P2X3 and P2X2/3 receptor-mediated calcium flux (Ki = 22 - 92 nM). Exhibits selectivity over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes (IC50 5 M). Reduces mechanical allodynia and thermal hyperalgesia in the CCI in vivo models. Antinociceptive.

catalog number base :

6493

product keywords :

A317491 selective high affinity non-nucleotide P2X3 P2X2/3 receptor antagonists antagonism antinociceptive mechanical allodynia hyperalgesia active in vivo P2X Receptors 6493,

extended description :

Selective, high affinity P2X3 and P2X2/3 antagonist; antinociceptive

chemical name text :

5-[[[(3-Phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid disodium salt

formula :

C 33 H 25 NO 8 Na 2

formula text :

C33H25NO8Na2

2020 USD :

545

2021 USD :

562 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage