chemical

A 317491 sodium salt

6493/5

5 mg (also 25 mg)

181 USD

6493

6493/5

A 317491 sodium salt

Selective, high affinity P2X3 and P2X2/3 antagonist; antinociceptive

P2X Receptor Antagonists

5 mg (also 25 mg)

Small Molecules

98%

Store at -20°C

609.54

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A 317491 sodium salt is a selective, high affinity non-nucleotide P2X3 and P2X2/3 receptor antagonist (Ki values are 9, 22, 22 and 92 nM at human P2X2/3, rat P2X3, human P2X3 and rat P2X2/3, respectively); blocks recombinant human and rat P2X3 and P2X2/3 receptor-mediated calcium flux (Ki = 22 - 92 nM). Exhibits selectivity over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes (IC50 5 M). Reduces mechanical allodynia and thermal hyperalgesia in the CCI in vivo models. Antinociceptive.

A317491 selective high affinity non-nucleotide P2X3 P2X2/3 receptor antagonists antagonism antinociceptive mechanical allodynia hyperalgesia active in vivo P2X Receptors 6493,

Selective, high affinity P2X3 and P2X2/3 antagonist; antinociceptive

5-[[[(3-Phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid disodium salt

C33H25NO8Na2

C33H25NO8Na2

179

181 USD

Selective, high affinity P2X3 and P2X2/3 antagonist; antinociceptive