chemical

GSK'872

6492

10 mg (also 50 mg)

169 USD

6492

6492/10

GSK'872

Potent and selective RIP3 kinase inhibitor

RIP Kinase Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

383.49

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Potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC50 = 1.3 nM). Exhibits 1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts in vitro . Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 M).

6492

GSK872 potent selective receptor activating protein kinase 3 RIP3K inhibitors inhibits necroptosis necrosis RIPK3 Necroptosis RIP Kinases 6492, RIP 1, RIP Kinase, RIPK1, inihibitor

Potent and selective RIP3 kinase inhibitor

N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine

C 19 H 17 N 3 O 2 S 2

C19H17N3O2S2

1346546-69-7

162

169 USD

Store at -20°C