GSK'872 | Tocris Bioscience 6492/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK'872

catalog :

6492/10

quantity :

10 mg (also 50 mg)

price :

218 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Culbertson B, Garcia K, Markett D, Asgharian H, Chen L, Fish L, et al. A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression. Nat Cancer. 2023;4:682-698 pubmed publisher
Fritsch J, Frankenheim J, Marischen L, Vadasz T, Troeger A, Rose John S, et al. Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells. Cells. 2021;10: pubmed publisher
Zelic M, Pontarelli F, Woodworth L, Zhu C, Mahan A, Ren Y, et al. RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis. Cell Rep. 2021;35:109112 pubmed publisher
Lee K, Lee H, Han D, Moon W, Kim K, Oh H, et al. Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer. Breast Cancer Res. 2020;22:130 pubmed publisher
Bedient L, Pokharel S, Chiok K, Mohanty I, Beach S, Miura T, et al. Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis. Viruses. 2020;12: pubmed publisher

image

image 1 :

Cat.No. 6492 - GSK 872 C19H17N3O2S2 CAS No. 1346546-69-7

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6492

SKU :

6492/10

product name :

GSK'872

description :

Potent and selective RIP3 kinase inhibitor

target :

RIP Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

383.49

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 872 is a potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC50 = 1.3 nM). Exhibits 1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts in vitro . Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 M).

product keywords :

GSK872 potent selective receptor activating protein kinase 3 RIP3K inhibitors inhibits necroptosis necrosis RIPK3 Necroptosis RIP Kinases 6492, RIP 1, RIP Kinase, RIPK1, inihibitor

extended description :

Potent and selective RIP3 kinase inhibitor

chemical name text :

N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine

formula :

C19H17N3O2S2

formula text :

C19H17N3O2S2

cas num :

1346546-69-7

USD :

211

USD 2025 :

218 USD

product details :

Potent and selective RIP3 kinase inhibitor

more info or order :

Tocris Bioscience product webpage