GNE 2861 | Tocris Bioscience 6490 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GNE 2861

catalog :

6490

quantity :

5 mg

price :

214 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6490

SKU :

6490/5

product name :

GNE 2861

description :

Group II PAK inhibitor; potently inhibits PAK4 and PAK 6

target :

PAK Inhibitors

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

406.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of group II p21 activated kinases (PAK; IC50 values are 7.5, 126 and 36 nM for PAK4, PAK5 and PAK6, respectively). Displays selectivity for group II PAK over a panel of 222 kinases. Inhibits tumor cell proliferation, migration and invasion in two breast cancer cell lines. Also sensitizes tamoxifen-resistant breast cancer cell lines to tamoxifen (Cat. No. 6342) via PAK4-dependent regulation of estrogen receptor (ER ) target gene expression.

catalog number base :

6490

product keywords :

GNE2861 PAK Kinase p21 activated kinase inhibitors inhibits group II PAK4 PAK5 PAK6 P21-activated Kinases 6490, p21-Activated Kinases, p21-Activated Kinase, PAKs

extended description :

Group II PAK inhibitor; potently inhibits PAK4 and PAK 6

chemical name text :

1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol

formula :

C 22 H 26 N 6 O 2

formula text :

C22H26N6O2

cas num :

1394121-05-1

2020 USD :

205

2021 USD :

214 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage