6481/5 | Tocris Bioscience 6481/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6481/5

catalog :

6481/5

quantity :

5 mg

price :

322 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6481 - AP 14145 hydrochloride C18H17F3N4O.HCl

product information

master code :

6481

SKU :

6481/5

product name :

AP 14145 hydrochloride

unit size :

5 mg

description :

Negative allosteric modulator of KCa2 (SK) channels

target :

Ca2+-Activated Potassium Channel Modulators

category :

Small Molecules

purity :

98%

observed molecular weight :

398.81

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AP 14145 hydrochloride is a KCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 M). Increases the EC50 of Ca2+ on KCa2.3 channels by 3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model.

top caption :

Negative allosteric modulator of KCa2 (SK) channels

extended description :

Negative allosteric modulator of KCa2 (SK) channels

chemical name text :

N-[2-[[(1R)-1-[3-(Trifluoromethyl)phenyl]ethyl]amino]-1H-benzimidazol-7-yl]acetamide hydrochloride

formula :

C18H17F3N4O.HCl

formula text :

C18H17F3N4O.HCl

cas num :

2387505-59-9

USD :

322 USD

product details :

Negative allosteric modulator of KCa2 (SK) channels

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage