6480/5 | Tocris Bioscience 6480/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6480/5

catalog :

6480/5

quantity :

5 mg (also 25 mg)

price :

85 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Reichmann M, Tezera L, Vallejo A, Vukmirovic M, Xiao R, Reynolds J, et al. Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets. J Clin Invest. 2021;131: pubmed publisher

image

image 1 :

Cat.No. 6480 - GSK 583 C20H19FN4O2S CAS No. 1346547-00-9

product information

master code :

6480

SKU :

6480/5

product name :

GSK 583

unit size :

5 mg (also 25 mg)

description :

Potent RIPK2 inhibitor; orally bioavailable and cell permeable

target :

RIP Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

398.45

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 583 is a potent RIPK2 inhibitor (IC50 values are 2 and 5 nM at rat and human kinases, respectively). Displays selectivity for RIP2K over p38 , VEGFR2 and a panel of 300 kinases. Exhibits some inhibition at BRK and Aurora A. Also displays similar binding affinity, but no detectable functional activity at RIP3. Active in vivo . Moderately orally bioavailable and cell permeable.

top caption :

Potent RIPK2 inhibitor; orally bioavailable and cell permeable

extended description :

Potent RIPK2 inhibitor; orally bioavailable and cell permeable

chemical name text :

6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine

formula :

C20H19FN4O2S

formula text :

C20H19FN4O2S

cas num :

1346547-00-9

USD :

85 USD

product details :

Potent RIPK2 inhibitor; orally bioavailable and cell permeable

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage