A 410099.1 | Tocris Bioscience 6470 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 410099.1

catalog :

6470

quantity :

10 mg (also 50 mg)

price :

132 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Loeder S, Zenz T, Schnaiter A, Mertens D, Winkler D, Dohner H, et al. A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia. Cancer Res. 2009;69:8977-86 pubmed publisher

product information

brand :

Tocris

master code :

6470

SKU :

6470/10

product name :

A 410099.1

description :

High affinity XIAP antagonist; active in vivo

target :

IAP Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

505.09

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.

catalog number base :

6470

product keywords :

A410099.1 A4100991 XIAP antagonists antagonism inhibitors inhibits high affinity x-linked inhibitor of apoptosis IAP anticancer Inhibitor of Apoptosis (IAP) 6470,

extended description :

High affinity XIAP antagonist; active in vivo

chemical name text :

N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride

formula :

C 27 H 40 N 4 O 3 .HCl

formula text :

C27H40N4O3.HCl

cas num :

762274-58-8

2020 USD :

132

2021 USD :

132 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage