6470/10 | Tocris Bioscience 6470/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6470/10

catalog :

6470/10

quantity :

10 mg (also 50 mg)

price :

149 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Schwalm M, Berger L, Meuter M, Vasta J, Corona C, R xf6 hm S, et al. A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins. Front Cell Dev Biol. 2022;10:886537 pubmed publisher
Loeder S, Zenz T, Schnaiter A, Mertens D, Winkler D, Dohner H, et al. A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia. Cancer Res. 2009;69:8977-86 pubmed publisher

product information

master code :

6470

SKU :

6470/10

product name :

A 410099.1

unit size :

10 mg (also 50 mg)

description :

High affinity XIAP antagonist; active in vivo

target :

IAP Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

505.09

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A 410099.1 is a high affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.

top caption :

High affinity XIAP antagonist; active in vivo

extended description :

High affinity XIAP antagonist; active in vivo

chemical name text :

N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride

formula :

C27H40N4O3.HCl

formula text :

C27H40N4O3.HCl

cas num :

762274-58-8

USD :

149 USD

product details :

High affinity XIAP antagonist; active in vivo

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage