VH 032, amine | Tocris Bioscience 6462 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VH 032, amine

catalog :

6462

quantity :

100 mg

price :

515 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Smalley J, Adams G, Millard C, Song Y, Norris J, Schwabe J, et al. PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes. Chem Commun (Camb). 2020;56:4476-4479 pubmed publisher

product information

brand :

Tocris

master code :

6462

SKU :

6462/100

product name :

VH 032, amine

description :

Functionalized VHL ligand for PROTACs

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

unit size :

100 mg

purity :

98%

observed molecular weight :

503.49

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Derivative of the von Hippel-Lindau (VHL) ligand, VH 032; commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component. Supplied with a primary amine functional handle at a position known not to significantly affect binding to VHL, for ready conjugation to a linker/target protein ligand. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. . Require a different derivative? Get in touch

catalog number base :

6462

product keywords :

VH032 amine 2HCl protein degrader 1 VHL VL 269 PROTACs E3 ligase ligands Functionalized E3 Ligase Ligands 6462,

extended description :

Functionalized VHL ligand for PROTACs

chemical name text :

(4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride

formula :

C 22 H 30 N 4 O 3 S.2HCl

formula text :

C22H30N4O3S.2HCl

cas num :

2137142-47-1

2020 USD :

495

2021 USD :

515 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage