6460/10 | Tocris Bioscience 6460/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6460/10

catalog :

6460/10

quantity :

10 mg (also 50 mg)

price :

189 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6460 - ABX 464 C16H10ClF3N2O CAS No. 1258453-75-6

product information

master code :

6460

SKU :

6460/10

product name :

ABX 464

unit size :

10 mg (also 50 mg)

description :

HIV RNA splicing modulator

target :

DNA, RNA and Protein Synthesis Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

338.71

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ABX 464 is an HIV RNA splicing modulator; it selectively enhances the splicing of HIV RNA in infected human PBMCs and inhibits viral replication, with no global effect on cellular splicing. ABX 464 inhibits replication of HIV strains harboring mutations associated with drug-resistance. ABX 464 binds the cap binding complex (CBC) and upregulates miR-124 expression in vitro and decreases expression of miR-124 target genes, MCP-1, CXCL-1, SERPIN-E1 in macrophages. It also decreases the number of Th17 cells, as well as IL-6 soluble receptor in CD4+ T cells. In HIV infected humanized mice, treatment with ABX 464 reduces viral load. Anti-inflammatory.

top caption :

HIV RNA splicing modulator

extended description :

HIV RNA splicing modulator

chemical name text :

8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine

formula :

C16H10ClF3N2O

formula text :

C16H10ClF3N2O

cas num :

1258453-75-6

USD :

189 USD

product details :

HIV RNA splicing modulator

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage