chemical

LY 2603618

6454

10 mg (also 50 mg)

216 USD

6454

6454/10

LY 2603618

Potent and selective Chk1 inhibitor

Checkpoint Kinase Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

436.3

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Potent and selective Chk1 inhibitor (IC50 = 7 nM). Inhibits Chk1 autophosphorylation. Induces cell cycle arrest in the G2/M phase and induces the DNA damage response in lung cancer cells. Inhibits growth of NSCLC xenografts in mice when administered in combination with Pemetrexed (Cat.No. 6185).

6454

LY2603618 checkpoint Chk1 inhibitors inhibits potent selective DNA damage response cell cycle arrest Checkpoint Control Kinases Checkpoint Kinases 6454,

Potent and selective Chk1 inhibitor

N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N -(5-methyl-2-pyrazinyl)urea

C 18 H 22 BrN 5 O 3

C18H22BrN5O3

911222-45-2

209

216 USD

Store at -20°C