6454/10 | Tocris Bioscience 6454/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6454/10

catalog :

6454/10

quantity :

10 mg (also 50 mg)

price :

242 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Taylor M, Thompson A, Alhajlah S, Tuxworth R, Ahmed Z. Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury. Sci Adv. 2022;8:eabq2611 pubmed publisher

image

image 1 :

Cat.No. 6454 - LY 2603618 C18H22BrN5O3 CAS No. 911222-45-2

product information

master code :

6454

SKU :

6454/10

product name :

LY 2603618

unit size :

10 mg (also 50 mg)

description :

Potent and selective Chk1 inhibitor

target :

Checkpoint Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

436.3

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LY 2603618 is a potent and selective Chk1 inhibitor (IC50 = 7 nM). Inhibits Chk1 autophosphorylation. Induces cell cycle arrest in the G2/M phase and induces the DNA damage response in lung cancer cells. Inhibits growth of NSCLC xenografts in mice when administered in combination with Pemetrexed (Cat.No. 6185).

top caption :

Potent and selective Chk1 inhibitor

extended description :

Potent and selective Chk1 inhibitor

chemical name text :

N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N -(5-methyl-2-pyrazinyl)urea

formula :

C18H22BrN5O3

formula text :

C18H22BrN5O3

cas num :

911222-45-2

USD :

242 USD

product details :

Potent and selective Chk1 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage