6451/10 | Tocris Bioscience 6451/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6451/10

catalog :

6451/10

quantity :

10 mg (also 50 mg)

price :

267 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6451 - Pexacerfont C18H24N6O CAS No. 459856-18-9

product information

master code :

6451

SKU :

6451/10

product name :

Pexacerfont

unit size :

10 mg (also 50 mg)

description :

Potent and selective CRF1 antagonist; anxiolytic

target :

CRF1 Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

340.43

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Pexacerfont is a potent and selective corticotropin-releasing factor 1 receptor (CRF1) antagonist (IC50 = 6.1 nM). Displays 150 fold selectivity for CRF1 over CRF2b. Inhibits CRF-mediated adrenocorticotropic hormone (ACTH) release from pituitary cell culture (IC50 = 129 nM). Displays anxiolytic effects in rat behavioral paradigms.

top caption :

Potent and selective CRF1 antagonist; anxiolytic

extended description :

Potent and selective CRF1 antagonist; anxiolytic

chemical name text :

8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine

formula :

C18H24N6O

formula text :

C18H24N6O

cas num :

459856-18-9

USD :

267 USD

product details :

Potent and selective CRF1 antagonist; anxiolytic

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage