6435/5 | Tocris Bioscience 6435/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6435/5

catalog :

6435/5

quantity :

5 mg (also 25 mg)

price :

93 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Liang Q, Dexheimer T, Zhang P, Rosenthal A, Villamil M, You C, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014;10:298-304 pubmed publisher

product information

master code :

6435

SKU :

6435/5

product name :

ML 323

unit size :

5 mg (also 25 mg)

description :

Potent and selective USP1-UAF1 allosteric inhibitor

target :

Deubiquitinating Enzyme Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

384.48

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ML 323 is a potent and selective allosteric inhibitor of USP1-UAF1 deubiquitinase complex (IC50 = 76 nM). Exhibits selectivity for USP1-UAF1 over a panel of enzymes, including other deuquitinating enzymes. Inhibits deubiquitination of PCNA and FANCD2 and sensitizes cisplatin-resistant H596 cells to cell death induced by cisplatin (Cat. No. 2251) in vitro .

top caption :

Potent and selective USP1-UAF1 allosteric inhibitor

extended description :

Potent and selective USP1-UAF1 allosteric inhibitor

chemical name text :

5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine

formula :

C23H24N6

formula text :

C23H24N6

cas num :

1572414-83-5

USD :

93 USD

product details :

Potent and selective USP1-UAF1 allosteric inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage