6433/10 | Tocris Bioscience 6433/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6433/10

catalog :

6433/10

quantity :

10 mg (also 50 mg)

price :

265 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Kwon D, Zhang F, McCray B, Feng S, Kumar M, Sullivan J, et al. TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun. 2023;14:3732 pubmed publisher
Daneva Z, Ottolini M, Chen Y, Klimentova E, Kuppusamy M, Shah S, et al. Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice. elife. 2021;10: pubmed publisher
Garth J, Easter M, Skylar Harris E, Sailland J, Kuenzi L, Chung S, et al. The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance. Front Med (Lausanne). 2019;6:339 pubmed publisher

image

image 1 :

Cat.No. 6433 - GSK 1016790A C28H32Cl2N4O6S2 CAS No. 942206-85-1

product information

master code :

6433

SKU :

6433/10

product name :

GSK 1016790A

unit size :

10 mg (also 50 mg)

description :

Potent TRPV4 agonist; active in vivo

target :

TRPV Agonists

category :

Small Molecules

purity :

97%

observed molecular weight :

655.61

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 1016790A is a potent TRPV4 agonist; elicits Ca2+ influx in human and mouse TRPV4-expressing HEK cells (EC50 values of 2.1 and 18 nM, respectively). Enhances insulin mRNA expression. Increases ERK1/2 phosphorylation and NO production. Exhibits no activity at TRPM8 and TRPA1 (20 M) channels. Induces bladder overactivity in TRPV4+/+ mice.

top caption :

Potent TRPV4 agonist; active in vivo

extended description :

Potent TRPV4 agonist; active in vivo

chemical name text :

N-[(1S)-1-[[4-[(2S)-2-[[(2,4-Dichlorophenyl)sulfonyl]amino]-3-hydroxy-1-oxopropyl]-1-piperazinyl]carbonyl]-3-methylbutyl]benzo[b]thiophene-2-carboxamide

formula :

C28H32Cl2N4O6S2

formula text :

C28H32Cl2N4O6S2

cas num :

942206-85-1

USD :

265 USD

product details :

Potent TRPV4 agonist; active in vivo

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage