chemical

ML 210

6429

10 mg

181 USD

6429

6429/10

ML 210

Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

Ras GTPase Inhibitors

Small Molecules

10 mg

98%

475.32

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Glutathione peroxidase (GPX4) inhibitor. Kills mutant RAS-expressing cell lines (IC50 values are 71 and 272 nM for HRAS G12v mutant expressing cell lines BJeLR and BJeH-LT, respectively). Exhibits 4-fold selectivity for HRAS mutant-expressing cell lines. Induces ferroptosis in tumor initiation persister cells and drug-resistant tumor cells.

6429

ML210 Glutathione peroxidases GPX4 inhibitors inhibits synthetically lethal compounds mutant RAS HRAS ferroptosis tumor initiation cells persister cells drug resistant TICs Ras GTPases Ferroptosis Cancer Stem Cells 6429, Ras, GTP ase

Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone

C 22 H 20 Cl 2 N 4 O 4

C22H20Cl2N4O4

1360705-96-9

175

181 USD

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