6429/10 | Tocris Bioscience 6429/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6429/10

catalog :

6429/10

quantity :

10 mg

price :

228 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Nassar Z, Mah C, Dehairs J, Burvenich I, Irani S, Centenera M, et al. Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. elife. 2020;9: pubmed publisher

product information

master code :

6429

SKU :

6429/10

product name :

ML 210

unit size :

10 mg

description :

Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

target :

Ras GTPase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

475.32

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ML 210 is a glutathione peroxidase (GPX4) inhibitor. Kills mutant RAS-expressing cell lines (IC50 values are 71 and 272 nM for HRAS G12v mutant expressing cell lines BJeLR and BJeH-LT, respectively). Exhibits 4-fold selectivity for HRAS mutant-expressing cell lines. Induces ferroptosis in tumor initiation persister cells and drug-resistant tumor cells.

top caption :

Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

extended description :

Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

chemical name text :

[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone

formula :

C22H20Cl2N4O4

formula text :

C22H20Cl2N4O4

cas num :

1360705-96-9

USD :

228 USD

product details :

Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage