chemical

PSEM 89S

6426

25 mg

609 USD

6426

6426/25

PSEM 89S

PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist

Pharmacologically Selective Effector Molecules/PSEM

Small Molecules

25 mg

98%

404.38

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PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist (EC50 values are 3.4 and 2.2 M, respectively). Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro . Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo , leading to suppression of feeding. Brain penetrant. . Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.

6426

PSEM89S PSAM L141F-GlyR chimeric channel pharmacologically selective actuator module agonists agonism activates activators L141F,Y115F-5HT3 5-HT3 effector modules chemogenetics Glycine Receptors 5-HT3 Receptors PSEMs 6426, Chemogenetics, Pharmacologically Selective Effector Molecules, PSAM Agonist, Pharmacologically Selective Actuator Module Agonists, PSEM, PSEMs

PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist

N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate

C 16 H 22 N 2 O 3 .CF 3 CO 2 H

C16H22N2O3.CF3CO2H

1336913-03-1

597

609 USD

Store at -20°C