chemical

PSEM 308 hydrochloride

6425

25 mg

628 USD

6425

6425/25

PSEM 308 hydrochloride

PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist

Pharmacologically Selective Effector Molecules/PSEM

Small Molecules

25 mg

98%

303.83

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PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels. . Recommended concentration for use in mice is 5 mg/kg or lower. . Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.

6425

PSEM308 HCl PSAM L141F-GlyR chimeric channel pharmacologically selective actuator molecule agonists agonism activates activators L141F,Y115F-5HT3 effector modules chemogenetics Glycine Receptors 5-HT3 Receptors PSEMs 6425, Chemogenetics, Pharmacologically Selective Effector Molecules, PSAM Agonist, Pharmacologically Selective Actuator Module Agonists, PSEM, PSEMs

PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist

5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyrido[3 ,2 :3,4]diazepino[6,7,1-hi]indole hydrochloride

C 17 H 21 N 3 .HCl

C17H21N3.HCl

603

628 USD

Store at -20°C