6416/5 | Tocris Bioscience 6416/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6416/5

catalog :

6416/5

quantity :

5 mg

price :

455 USD

more info or order :

Tocris Bioscience product webpage

product information

master code :

6416

SKU :

6416/5

product name :

CM 11

unit size :

5 mg

description :

Homo-PROTAC for self-degradation of pVHL30

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

1179.46

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CM 11 is a PROTAC for self-degradation of the long form of VHL, pVHL30 (DC50 100 nM). Composed of two VHL ligands joined by a linker. Exhibits 1000-fold increased cellular activity compared to the parent VHL ligand, VH 032. Dimerizes pVHL30 with high avidity in vitro . Induced potent and rapid self-degradation of VHL in cell lines in a highly isoform dependent fashion. Negative control CMP 98 (Cat. No. 6417) also available. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

Homo-PROTAC for self-degradation of pVHL30

extended description :

Homo-PROTAC for self-degradation of pVHL30

chemical name text :

N1,N20-bis((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide

formula :

C58H82N8O14S2

formula text :

C58H82N8O14S2

cas num :

2244684-49-7

USD :

455 USD

product details :

Homo-PROTAC for self-degradation of pVHL30

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage