A 1210477 | Tocris Bioscience 6409 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 1210477

catalog :

6409

quantity :

25 mg

price :

301 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6409

SKU :

6409/25

product name :

A 1210477

description :

Selective, high affinity Mcl-1 inhibitor; proapoptotic

target :

Bcl-2 Family Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

850.04

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective, high affinity Mcl-1 inhibitor (Ki = 454 pM). Disrupts Mcl-BIM complexes (IC50 in low M range). Also inhibits Mcl-1NOXA interactions. Exhibits no effect on Bcl-XL-Bim or Bcl-X-BCL-Xs interactions. Induces apoptosis in multiple myeloma and non-small cell lung cancer cell lines and exhibits a synergistic effect with NavitoclaxTM to induce apoptosis in vitro . Cell permeable.

catalog number base :

6409

product keywords :

A1210477 Mcl-1 inhibitors inhibits apoptosis proapoptotic selective high affinity multiple myeloma non-small cell lung cancer Bcl-2 Family 6409,

extended description :

Selective, high affinity Mcl-1 inhibitor; proapoptotic

chemical name text :

7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid

formula :

C 46 H 55 N 7 O 7 S

formula text :

C46H55N7O7S

cas num :

1668553-26-1

2020 USD :

295

2021 USD :

301 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage