6390/1 | Tocris Bioscience 6390/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6390/1

catalog :

6390/1

quantity :

1 mg (also 10 mg)

price :

245 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Jerber J, Seaton D, Cuomo A, Kumasaka N, Haldane J, Steer J, et al. Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation. Nat Genet. 2021;53:304-312 pubmed publisher
Yalcınkaya M, Kerksiek A, Gebert K, Annema W, Sibler R, Radosavljevic S, et al. HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened. J Lipid Res. 2020;61:492-504 pubmed publisher
Galati D, Sullivan K, Pham A, Espinosa J, Pearson C. Trisomy 21 Represses Cilia Formation and Function. Dev Cell. 2018;46:641-650.e6 pubmed publisher

product information

master code :

6390

SKU :

6390/1

product name :

SAG dihydrochloride

unit size :

1 mg (also 10 mg)

description :

Dihydrochloride salt of SAG; Smo receptor agonist

target :

Smoothened Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

562.98

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SAG dihydrochloride is a water-soluble dihydrochloride salt of SAG (Cat. No. 4366). SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM) and induces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons. The compound can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

top caption :

Dihydrochloride salt of SAG; Smo receptor agonist

extended description :

Dihydrochloride salt of SAG; Smo receptor agonist

chemical name text :

3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride

formula :

C28H28ClN3OS.2HCl

formula text :

C28H28ClN3OS.2HCl

cas num :

2702366-44-5

USD :

245 USD

product details :

Dihydrochloride salt of SAG; Smo receptor agonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage