A 485 | Tocris Bioscience 6387 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 485

catalog :

6387

quantity :

25 mg

price :

987 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6387

SKU :

6387/25

product name :

A 485

description :

Potent and selective p300/CBP inhibitor; orally bioavailable

target :

Histone Acetyltransferase Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

536.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective p300/CREB-binding protein (CBP) HAT domain inhibitor (IC50 values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains, respectively). Displays 1000-fold selectivity over closely related HATs. Suppresses proliferation in several hematological malignancies and AR+ prostate cancer cell lines in vitro . Inhibits tumor growth in a castration-resistant prostate cancer xenograft model. Orally bioavailable. . To request the negative control for A 485, please fill out the A 486 request form on the SGC website.

catalog number base :

6387

product keywords :

A485 inhibitors inhibits histone acetyltransferase HAT PCAF p300 HSCs potent selective androgen receptor-positive prostate CBP Histone Acetyltransferases 6387,

extended description :

Potent and selective p300/CBP inhibitor; orally bioavailable

chemical name text :

(1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2 ,4 -dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5 -oxazolidine]-3 -acetamide

formula :

C 25 H 24 F 4 N 4 O 5

formula text :

C25H24F4N4O5

cas num :

1889279-16-6

2020 USD :

940

2021 USD :

987 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage