6367/10 | Tocris Bioscience 6367/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6367/10

catalog :

6367/10

quantity :

10 mg (also 50 mg)

price :

281 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Baker S, Leigh W, Del Valle G, De Yturriaga I, Ward S, Cobine C, et al. Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon. elife. 2021;10: pubmed publisher
Hsiao K, Noble C, Pitman W, Yadav N, Kumar S, Keele G, et al. A Thalamic Orphan Receptor Drives Variability in Short-Term Memory. Cell. 2020;183:522-536.e19 pubmed publisher

image

image 1 :

Cat.No. 6367 - Z 944 C19H27ClFN3O2 CAS No. 1199236-64-0

product information

master code :

6367

SKU :

6367/10

product name :

Z 944

unit size :

10 mg (also 50 mg)

description :

CaV3.x blocker

target :

Voltage-gated Calcium Channel Blockers

category :

Small Molecules

purity :

98%

observed molecular weight :

383.89

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Z 944 is a selective T-type Ca2+ channel blocker (IC50 values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties in isolated heart Purkinje fibers and no adverse effects on ECG parameters in vivo . Exhibits anti-seizure effects in animal models.

top caption :

CaV3.x blocker

extended description :

CaV3.x blocker

chemical name text :

4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide

formula :

C19H27ClFN3O2

formula text :

C19H27ClFN3O2

cas num :

1199236-64-0

USD :

281 USD

product details :

CaV3.x blocker

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage